6p5v

X-ray diffraction
1.4Å resolution

Structure of DCN1 bound to N-((4S,5S)-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-methylbenzamide

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DCN1-like protein 1; Endolysin Chain: A
Molecule details ›
Chain: A
Length: 384 amino acids
Theoretical weight: 44.31 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: D9IEF7 (Residues: 1-164; Coverage: 100%)
  • Canonical: Q96GG9 (Residues: 62-259; Coverage: 76%)
Gene names: DCN1, DCUN1D1, DCUN1L1, RP42, SCCRO, T4Tp126, e
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 35.31Å b: 96.985Å c: 60.072Å
α: 90° β: 106.09° γ: 90°
R-values:
R R work R free
0.173 0.171 0.205
Expression system: Escherichia coli