› 6p4u

X-ray diffraction
2.1Å resolution

The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with Mg and AMP

Released:
DOI: 10.2210/pdb6p4u/pdb
PDB entry 6p4u coloured by chain, front view.
PDB entry 6p4u coloured by chain, side view.
PDB entry 6p4u coloured by chain, top view.
Source organism: Eleftheria terrae
Primary publication:
Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains.
Tan K, Zhou M, Jedrzejczak RP, Wu R, Higuera RA, Borek D, Babnigg G, Joachimiak A
Curr Res Struct Biol 2 14-24 (2020)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-101002 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carrier domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 873 amino acids
Theoretical weight: 96.57 KDa
Source organism: Eleftheria terrae
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0B5GUD2 (Residues: 2140-3009; Coverage: 14%)
Sequence domains:

Ligands and Environments

7 bound ligands:
Ligand AMP 1 x AMP
Ligand MG 1 x MG
Ligand SO4 17 x SO4
Ligand CL 1 x CL
Ligand ACT 1 x ACT
Ligand GOL 2 x GOL
Ligand FMT 1 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 154.232Å b: 90.828Å c: 98.463Å
α: 90° β: 106.1° γ: 90°
R-values:
R R work R free
0.21 0.208 0.237
Expression system: Escherichia coli

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