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Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT449

X-ray diffraction
2.5Å resolution
PDB entry 6p3t coloured by chain, front view.
PDB entry 6p3t coloured by chain, side view.
PDB entry 6p3t coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: N-acetyltransferase Eis
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Multimeric state: homo hexamer
Accessible surface area: 85476.97 Å2
Buried surface area: 39403.15 Å2
Dissociation area: 5,219.62 Å2
Dissociation energy (ΔGdiss): 29.73 kcal/mol
Dissociation entropy (TΔSdiss): 31.98 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-161420

Macromolecules

N-acetyltransferase Eis
Chain: A
Length: 422 amino acids
Theoretical weight: 46 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WFK7 (Residues: 1-402; Coverage: 100%)
Gene names: MTCY253.04, Rv2416c, eis
Pfam:
InterPro:
N-acetyltransferase Eis in PDB entry 6p3t, assembly 1, front view.
N-acetyltransferase Eis in PDB entry 6p3t, assembly 1, side view.
N-acetyltransferase Eis in PDB entry 6p3t, assembly 1, top view.
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