6p3t

X-ray diffraction
2.5Å resolution

Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT449

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-acetyltransferase Eis Chain: A
Molecule details ›
Chain: A
Length: 422 amino acids
Theoretical weight: 46 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WFK7 (Residues: 1-402; Coverage: 100%)
Gene names: MTCY253.04, Rv2416c, eis
Sequence domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R32
Unit cell:
a: 175.636Å b: 175.636Å c: 122.749Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.167 0.205
Expression system: Escherichia coli BL21(DE3)