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Structure of a nested set of N-terminally extended MHC I-peptides provides novel insights into antigen processing and presentation

X-ray diffraction
1.593Å resolution
PDB entry 6p27 coloured by chain, front view.
PDB entry 6p27 coloured by chain, side view.
PDB entry 6p27 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Major Histocompatibility Complex
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Multimeric state: hetero trimer
Accessible surface area: 18782.17 Å2
Buried surface area: 4323.01 Å2
Dissociation area: 1,265.7 Å2
Dissociation energy (ΔGdiss): 7.32 kcal/mol
Dissociation entropy (TΔSdiss): 12.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135237

Macromolecules

HLA class I histocompatibility antigen, B alpha chain
Chain: A
Length: 276 amino acids
Theoretical weight: 31.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01889 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Pfam:
InterPro:
HLA class I histocompatibility antigen, B alpha chain in PDB entry 6p27, assembly 1, front view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 6p27, assembly 1, side view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 6p27, assembly 1, top view.
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Beta-2-microglobulin
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
Beta-2-microglobulin in PDB entry 6p27, assembly 1, front view.
Beta-2-microglobulin in PDB entry 6p27, assembly 1, side view.
Beta-2-microglobulin in PDB entry 6p27, assembly 1, top view.
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MHC I-peptide
Chain: C
Length: 12 amino acids
Theoretical weight: 1.4 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
MHC I-peptide in PDB entry 6p27, assembly 1, front view.
MHC I-peptide in PDB entry 6p27, assembly 1, side view.
MHC I-peptide in PDB entry 6p27, assembly 1, top view.
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