Function and Biology

CRYO-EM STRUCTURE OF PHOSPHORYLATED AP-2 CORE BOUND TO NECAP

Source organisms:
Biochemical function: clathrin adaptor activity
Biological process: vesicle-mediated transport
Cellular component: plasma membrane

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01602
Domain description: Adaptin N terminal region
Occurring in:
  1. AP-2 complex subunit alpha-2
  2. AP-2 complex subunit beta
1 copy of Pfam domain PF01602 (Adaptin N terminal region) in AP-2 complex subunit alpha-2 in PDB 6owo.
2 copies of Pfam domain PF01602 (Adaptin N terminal region) in AP-2 complex subunit beta in PDB 6owo.

PF01217
Domain description: Clathrin adaptor complex small chain
Occurring in:
  1. AP-2 complex subunit mu
  2. AP-2 complex subunit sigma
1 copy of Pfam domain PF01217 (Clathrin adaptor complex small chain) in AP-2 complex subunit mu in PDB 6owo.
2 copies of Pfam domain PF01217 (Clathrin adaptor complex small chain) in AP-2 complex subunit sigma in PDB 6owo.

PF00928
Domain description: Adaptor complexes medium subunit family
Occurring in:
  1. AP-2 complex subunit mu
1 copy of Pfam domain PF00928 (Adaptor complexes medium subunit family) in AP-2 complex subunit mu in PDB 6owo.

PF07933
Domain description: Protein of unknown function (DUF1681)
Occurring in:
  1. Adaptin ear-binding coat-associated protein 2
1 copy of Pfam domain PF07933 (Protein of unknown function (DUF1681)) in Adaptin ear-binding coat-associated protein 2 in PDB 6owo.

InterPro InterPro annotations
IPR001392
Domain description: Clathrin adaptor, mu subunit
Occurring in:
  1. AP-2 complex subunit mu
IPR011012
Domain description: Longin-like domain superfamily
Occurring in:
  1. AP-2 complex subunit mu
  2. AP-2 complex subunit sigma
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. AP-2 complex subunit alpha-2
  2. AP-2 complex subunit beta
IPR016635
Domain description: Adaptor protein complex, sigma subunit
Occurring in:
  1. AP-2 complex subunit sigma
IPR000225
Domain description: Armadillo
Occurring in:
  1. AP-2 complex subunit beta
IPR012466
Domain description: NECAP, PHear domain
Occurring in:
  1. Adaptin ear-binding coat-associated protein 2
IPR002553
Domain description: Clathrin/coatomer adaptor, adaptin-like, N-terminal
Occurring in:
  1. AP-2 complex subunit alpha-2
  2. AP-2 complex subunit beta
IPR022775
Domain description: AP complex, mu/sigma subunit
Occurring in:
  1. AP-2 complex subunit mu
  2. AP-2 complex subunit sigma
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. AP-2 complex subunit alpha-2
  2. AP-2 complex subunit beta
IPR036168
Domain description: AP-2 complex subunit mu, C-terminal superfamily
Occurring in:
  1. AP-2 complex subunit mu
IPR028565
Domain description: Mu homology domain
Occurring in:
  1. AP-2 complex subunit mu
IPR026739
Domain description: AP complex subunit beta
Occurring in:
  1. AP-2 complex subunit beta
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Adaptin ear-binding coat-associated protein 2
IPR017107
Domain description: Adaptor protein complex AP-1, gamma subunit
Occurring in:
  1. AP-2 complex subunit alpha-2
IPR016342
Domain description: AP-1/2/4 complex subunit beta
Occurring in:
  1. AP-2 complex subunit beta
IPR027156
Domain description: AP-2 complex subunit sigma
Occurring in:
  1. AP-2 complex subunit sigma