6opq

Electron Microscopy
3.8Å resolution

CD4- and 17-bound HIV-1 Env B41 SOSIP frozen with LMNG

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
PDBe Complex ID:
PDB-CPX-207661 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (7 distinct):
Envelope glycoprotein gp160 Chains: A, D, E
Molecule details ›
Chains: A, D, E
Length: 524 amino acids
Theoretical weight: 58.87 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: B3UES2 (Residues: 29-517; Coverage: 57%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
17b Fab light chain Chains: L, N, O
Molecule details ›
Chains: L, N, O
Length: 214 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Transmembrane protein gp41 Chains: B, F, G
Molecule details ›
Chains: B, F, G
Length: 153 amino acids
Theoretical weight: 17.36 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: B3UEZ6 (Residues: 516-668; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
T-cell surface glycoprotein CD4 Chains: C, I, J
Molecule details ›
Chains: C, I, J
Length: 208 amino acids
Theoretical weight: 23.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01730 (Residues: 25-203; Coverage: 41%)
Gene name: CD4
Sequence domains:
17b Fab heavy chain Chains: H, K, M
Molecule details ›
Chains: H, K, M
Length: 229 amino acids
Theoretical weight: 24.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-20153
Expression system: Homo sapiens