6okp

Electron Microscopy
3.28Å resolution

B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-109935 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (13 distinct):
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 153 amino acids
Theoretical weight: 17.36 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
UniProt:
  • Canonical: B3UEZ6 (Residues: 516-668; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
Envelope glycoprotein gp160 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 516 amino acids
Theoretical weight: 57.7 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
UniProt:
  • Canonical: B3UES2 (Residues: 29-509; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Ig-like domain-containing protein Chain: K
Molecule details ›
Chain: K
Length: 244 amino acids
Theoretical weight: 26.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 20-117, 118-123, 124-243; Coverage: 50%)
Sequence domains:
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N5F4 (Residues: 29-85, 86-111, 112-233; Coverage: 96%)
Gene name: IGL@
Sequence domains:
Ig-like domain-containing protein Chains: M, O, Q
Molecule details ›
Chains: M, O, Q
Length: 241 amino acids
Theoretical weight: 26.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 20-117, 118-118, 119-125, 126-243; Coverage: 50%)
Sequence domains:
Immunoglobulin kappa constant Chains: N, P, R
Molecule details ›
Chains: N, P, R
Length: 212 amino acids
Theoretical weight: 23.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.28Å
Relevant EMDB volumes: EMD-20100
Expression systems:
  • Cricetulus griseus
  • Homo sapiens