› 6ocx

X-ray diffraction
1.9Å resolution

Structure of human CIB1 in complex with peptide inhibitor UNC10245109

Released:
DOI: 10.2210/pdb6ocx/pdb
PDB entry 6ocx coloured by chain, front view.
PDB entry 6ocx coloured by chain, side view.
PDB entry 6ocx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1.
Puhl AC, Bogart JW, Haberman VA, Larson JE, Godoy AS, Norris-Drouin JL, Cholensky SH, Leisner TM, Frye SV, Parise LV, Bowers AA, Pearce KH
ACS Chem Biol 15 1505-1516 (2020)
PMID: 32383857

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167194 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calcium and integrin-binding protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 191 amino acids
Theoretical weight: 21.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99828 (Residues: 1-191; Coverage: 100%)
Gene names: CIB, CIB1, KIP, PRKDCIP
Peptide inhibitor UNC10245109 Chains: F, H, J, L
Molecule details ›
Chains: F, H, J, L
Length: 15 amino acids
Theoretical weight: 1.72 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P21
Unit cell:
a: 75.866Å b: 33.035Å c: 162.402Å
α: 90° β: 99.85° γ: 90°
R-values:
R R work R free
0.214 0.212 0.246
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

Phage display derived peptides for Alzheimer's disease therapy and diagnosis.
Zhang et al. (2022)
1 more

2 mentions without citation

Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1.
Puhl et al. (2020)
1 more