X-ray diffraction
3.4Å resolution

Crystal structure of STING CTD in complex with TBK1


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Stimulator of interferon genes protein Chains: D, E
Molecule details ›
Chains: D, E
Length: 226 amino acids
Theoretical weight: 25.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q86WV6 (Residues: 155-379; Coverage: 59%)
Gene names: ERIS, MITA, STING1, TMEM173
Serine/threonine-protein kinase TBK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 665 amino acids
Theoretical weight: 76.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q9UHD2 (Residues: 2-657; Coverage: 90%)
Gene names: NAK, TBK1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P6522
Unit cell:
a: 250.69Å b: 250.69Å c: 239.241Å
α: 90° β: 90° γ: 120°
R R work R free
0.244 0.244 0.258
Expression systems:
  • Escherichia coli BL21(DE3)
  • Spodoptera frugiperda