› 6o5w

X-ray diffraction
1.41Å resolution

Crystal structure of MORC3 CW domain fused with viral influenza A NS1 peptide

Released:
DOI: 10.2210/pdb6o5w/pdb
PDB entry 6o5w coloured by chain, front view.
PDB entry 6o5w coloured by chain, side view.
PDB entry 6o5w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
MORC3 Is a Target of the Influenza A Viral Protein NS1.
Zhang Y, Ahn J, Green KJ, Vann KR, Black J, Brooke CB, Kutateladze TG
Structure 27 1029-1033.e3 (2019)
PMID: 31006586

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171941 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MORC family CW-type zinc finger protein 3 Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14149 (Residues: 407-455; Coverage: 5%)
Gene names: KIAA0136, MORC3, NXP2, ZCWCC3
Sequence domains: CW-type Zinc Finger
Structure domains: Herpes Virus-1

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 30.912Å b: 37.424Å c: 50.314Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.169
Expression system: Escherichia coli

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Citations

5 review citations

Mechanistic similarities in recognition of histone tails and DNA by epigenetic readers.
Vann et al. (2021)
4 more