X-ray diffraction
2.8Å resolution

Room temperature structure of binary complex of native hAChE with oxime reactivator RS-170B


Function and Biology Details

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Acetylcholinesterase Chains: A, B
Molecule details ›
Chains: A, B
Length: 550 amino acids
Theoretical weight: 60.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: P22303 (Residues: 32-578; Coverage: 94%)
Gene name: ACHE
Sequence domains: Carboxylesterase family

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P31
Unit cell:
a: 125.609Å b: 125.609Å c: 131.428Å
α: 90° β: 90° γ: 120°
R R work R free
0.166 0.165 0.189
Expression system: Homo sapiens