› 6o26

X-ray diffraction
1.8Å resolution

Crystal structure of 3246 Fab in complex with circumsporozoite protein NANA

Released:
DOI: 10.2210/pdb6o26/pdb
PDB entry 6o26 coloured by chain, front view.
PDB entry 6o26 coloured by chain, side view.
PDB entry 6o26 coloured by chain, top view.
Source organisms:
Primary publication:
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs.
Murugan R, Scally SW, Costa G, Mustafa G, Thai E, Decker T, Bosch A, Prieto K, Levashina EA, Julien JP, Wardemann H
Nat Med 26 1135-1145 (2020)
PMID: 32451496

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210766 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
3246 Fab heavy chain Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
3246 Fab light chain Chain: B
Molecule details ›
Chain: B
Length: 214 amino acids
Theoretical weight: 23.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Circumsporozoite protein Chain: C
Molecule details ›
Chain: C
Length: 14 amino acids
Theoretical weight: 1.49 KDa
Source organism: Plasmodium falciparum
Expression system: Not provided
UniProt:
  • Canonical: P19597 (Residues: 289-302; Coverage: 4%)
Gene name: CSP

Ligands and Environments

3 bound ligands:
Ligand TRS 1 x TRS
Ligand EDO 1 x EDO
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Unit cell:
a: 67.141Å b: 68.682Å c: 104.212Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.163 0.207
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

3 review citations

Host-parasite interactions during Plasmodium infection: Implications for immunotherapies.
Chandley et al. (2022)
2 more