PDBe 6o0l

X-ray diffraction
2.2Å resolution

crystal structure of BCL-2 G101V mutation with venetoclax

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator Bcl-2; Bcl-2-like protein 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 166 amino acids
Theoretical weight: 19.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q07817 (Residues: 29-44; Coverage: 7%)
  • Canonical: P10415 (Residues: 1-34, 66-207; Coverage: 63%)
  • nullnull
Gene names: BCL2, BCL2L, BCL2L1, BCLX
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 33.147Å b: 82.005Å c: 47.508Å
α: 90° β: 90.08° γ: 90°
R-values:
R R work R free
0.197 0.195 0.227
Expression system: Escherichia coli BL21