› 6nrl

X-ray diffraction
3.2Å resolution

X-ray structure of H6N6-NS1 delta(80-84) R38A K41A E71G mutant

Released:
DOI: 10.2210/pdb6nrl/pdb
PDB entry 6nrl coloured by chain, front view.
PDB entry 6nrl coloured by chain, side view.
PDB entry 6nrl coloured by chain, top view.
Source organism: Influenza A virus (A/blue-winged teal/LA/B182/86(H4N6))
Primary publication:
Influenza A Virus Protein NS1 Exhibits Strain-Independent Conformational Plasticity.
Mitra S, Kumar D, Hu L, Sankaran B, Moosa MM, Rice AP, Ferreon JC, Ferreon ACM, Prasad BVV
J Virol 93 (2019)
PMID: 31375595

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174132 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-structural protein 1 Chain: A
Molecule details ›
Chain: A
Length: 195 amino acids
Theoretical weight: 22 KDa
Source organism: Influenza A virus (A/blue-winged teal/LA/B182/86(H4N6))
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2Y234 (Residues: 4-203; Coverage: 85%)
Gene name: NS
Sequence domains: Influenza non-structural protein (NS1)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P6522
Unit cell:
a: 105.19Å b: 105.19Å c: 80.21Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.243 0.259
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection.
Rosário-Ferreira et al. (2020)
1 more

2 mentions without citation

Influenza A Virus Protein NS1 Exhibits Strain-Independent Conformational Plasticity.
Mitra et al. (2019)
1 more