› 6nfx

X-ray diffraction
1.95Å resolution

MBTD1 MBT repeats

Released:
DOI: 10.2210/pdb6nfx/pdb
PDB entry 6nfx coloured by chain, front view.
PDB entry 6nfx coloured by chain, side view.
PDB entry 6nfx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.
Zhang H, Devoucoux M, Song X, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J, Min J
Cell Rep 30 3996-4002.e4 (2020)
PMID: 32209463

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170274 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enhancer of polycomb homolog 1; MBT domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 470 amino acids
Theoretical weight: 52.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05BQ5 (Residues: 140-562; Coverage: 67%)
  • Canonical: Q9H2F5 (Residues: 644-671; Coverage: 3%)
Gene names: EPC1, MBTD1
Sequence domains: mbt repeat

Ligands and Environments

3 bound ligands:
Ligand UNX 38 x UNX
Ligand NA 1 x NA
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 68.607Å b: 124.724Å c: 70.057Å
α: 90° β: 92.88° γ: 90°
R-values:
R R work R free
0.187 0.185 0.221
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Multifaceted regulation and functions of 53BP1 in NHEJ‑mediated DSB repair (Review).
Lei et al. (2022)
1 more