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CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2

Source organisms:
Biochemical function: toxin activity
Biological process: modulation of process of another organism
Cellular component: extracellular region

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00520
Domain description: Ion transport protein
Occurring in:
  1. Ion transport domain-containing protein; Sodium channel protein type 9 subunit alpha
The deposited structure of PDB entry 6n4q contains 8 copies of Pfam domain PF00520 (Ion transport protein) in Ion transport domain-containing protein. Showing 2 copies in chain B.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Fab light chain
  2. Fab heavy chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Fab light chain
  2. Fab heavy chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Fab light chain
  2. Fab heavy chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Fab light chain
  2. Fab heavy chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Fab light chain
  2. Fab heavy chain
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Fab light chain
  2. Fab heavy chain
IPR043203
Domain description: Voltage-gated cation channel calcium and sodium
Occurring in:
  1. Ion transport domain-containing protein; Sodium channel protein type 9 subunit alpha
IPR005821
Domain description: Ion transport domain
Occurring in:
  1. Ion transport domain-containing protein; Sodium channel protein type 9 subunit alpha
IPR027359
Domain description: Voltage-dependent channel domain superfamily
Occurring in:
  1. Ion transport domain-containing protein; Sodium channel protein type 9 subunit alpha
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Fab light chain

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Fab light chain
The deposited structure of PDB entry 6n4q contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Fab light chain. Showing 2 copies in chain I.

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