› 6n2p

Electron Microscopy
4Å resolution

Helical assembly of the CARD9 CARD

Released:
DOI: 10.2210/pdb6n2p/pdb
PDB entry 6n2p coloured by chain, front view.
PDB entry 6n2p coloured by chain, side view.
PDB entry 6n2p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Holliday MJ, Witt A, Rodríguez Gama A, Walters BT, Arthur CP, Halfmann R, Rohou A, Dueber EC, Fairbrother WJ
Nat Commun 10 3070 (2019)
PMID: 31296852
Related structures: EMD-9332

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190537 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase recruitment domain-containing protein 9 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 152 amino acids
Theoretical weight: 17.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H257 (Residues: 2-152; Coverage: 28%)
Gene name: CARD9
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-9332
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

CARD9 Signaling, Inflammation, and Diseases.
Liu et al. (2022)
5 more

2 mentions without citation

Assembly of platforms for signal transduction in the new era: dimerization, helical filament assembly, and beyond.
Ha et al. (2020)
1 more