6mxb

X-ray diffraction
2.19Å resolution

Crystal structure of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltranferase in complex with XMP

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pribosyltran domain-containing protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 272 amino acids
Theoretical weight: 30.64 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli
UniProt:
  • Canonical: Q38CA1 (Residues: 2-234; Coverage: 100%)
Gene name: Tb10.70.6660
Sequence domains: Phosphoribosyl transferase domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 61.113Å b: 107.394Å c: 117.097Å
α: 90° β: 96.96° γ: 90°
R-values:
R R work R free
0.186 0.185 0.223
Expression system: Escherichia coli