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Dimeric DARPin A_distance_R7 complex with EpoR

X-ray diffraction
5.101Å resolution
PDB entry 6mok coloured by chain, front view.
PDB entry 6mok coloured by chain, side view.
PDB entry 6mok coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Erythropoietin receptor
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Multimeric state: hetero tetramer
Accessible surface area: 42691.87 Å2
Buried surface area: 5588.54 Å2
Dissociation area: 2,036.63 Å2
Dissociation energy (ΔGdiss): -5.29 kcal/mol
Dissociation entropy (TΔSdiss): 27.15 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148535

Macromolecules

Dimeric DARPin ANR7 (A_distance_r7)
Chain: A
Length: 296 amino acids
Theoretical weight: 30.74 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
InterPro:
Dimeric DARPin ANR7 (A_distance_r7) in PDB entry 6mok, assembly 1, front view.
Dimeric DARPin ANR7 (A_distance_r7) in PDB entry 6mok, assembly 1, side view.
Dimeric DARPin ANR7 (A_distance_r7) in PDB entry 6mok, assembly 1, top view.
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Erythropoietin receptor
Chain: B
Length: 229 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19235 (Residues: 32-249; Coverage: 45%)
Gene name: EPOR
Pfam:
InterPro:
Erythropoietin receptor in PDB entry 6mok, assembly 1, front view.
Erythropoietin receptor in PDB entry 6mok, assembly 1, side view.
Erythropoietin receptor in PDB entry 6mok, assembly 1, top view.
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