EC 2.7.11.11: cAMP-dependent protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (cAMP-dependent)
Alternative Name(s):
- PKA
- PKA C
- Protein kinase A
- STK22
GO terms
Biochemical function:
- protein serine kinase activity
- protein-containing complex binding
- protein kinase A regulatory subunit binding
- ubiquitin protein ligase binding
- small GTPase binding
- manganese ion binding
- protein domain specific binding
- protein kinase binding
- ATP binding
- protein binding
- protein serine/threonine/tyrosine kinase activity
- cAMP-dependent protein kinase activity
- AMP-activated protein kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
- magnesium ion binding
Biological process:
- calcium ion transport
- regulation of bicellular tight junction assembly
- protein localization to lipid droplet
- negative regulation of glycolytic process through fructose-6-phosphate
- negative regulation of TORC1 signaling
- postsynaptic modulation of chemical synaptic transmission
- cellular response to glucagon stimulus
- cellular response to parathyroid hormone stimulus
- cellular response to glucose stimulus
- regulation of protein processing
- cellular response to cold
- regulation of proteasomal protein catabolic process
- regulation of synaptic transmission, glutamatergic
- regulation of cell cycle
- negative regulation of meiotic cell cycle
- modulation of chemical synaptic transmission
- spontaneous exocytosis of neurotransmitter
- sperm capacitation
- positive regulation of protein export from nucleus
- negative regulation of smoothened signaling pathway
- positive regulation of gluconeogenesis
- regulation of osteoblast differentiation
- regulation of cellular respiration
- cellular response to heat
- positive regulation of insulin secretion
- peptidyl-serine phosphorylation
- protein kinase A signaling
- positive regulation of cell population proliferation
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- protein export from nucleus
- protein phosphorylation
- mRNA processing
- neural tube closure
- mesoderm formation
- negative regulation of transcription by RNA polymerase II
Cellular component:
- glutamatergic synapse
- postsynapse
- presynapse
- ciliary base
- perinuclear region of cytoplasm
- plasma membrane raft
- dendritic spine
- sperm flagellum
- protein-containing complex
- neuromuscular junction
- motile cilium
- cytoplasmic vesicle
- nuclear speck
- cAMP-dependent protein kinase complex
- axoneme
- plasma membrane
- cytosol
- centrosome
- mitochondrion
- cytoplasm
- nucleoplasm
- nucleus
- acrosomal vesicle
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 6mm6 contains 2 copies of Pfam domain PF00069 (Protein kinase domain) in cAMP-dependent protein kinase catalytic subunit alpha. Showing 1 copy in chain A [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6mm6_1_C_Pfam_PF00069_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6mm6</span> contains 2 copies of Pfam domain <span class='highlight'>PF00069 (Protein kinase domain)</span> in <span class='highlight'>cAMP-dependent protein kinase catalytic subunit alpha</span>. Showing 1 copy in chain <span class='highlight'>A [auth C]</span>.")
InterPro annotations
Structure domains
CATH domains
1.10.490.160
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Globin-like
Homology:
Globin-like
Occurring in:
3.30.200.20
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Phosphorylase Kinase; domain 1
Homology:
Phosphorylase Kinase; domain 1
Occurring in:
![The deposited structure of PDB entry 6mm6 contains 2 copies of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in cAMP-dependent protein kinase catalytic subunit alpha. Showing 1 copy in chain A [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6mm6_1_C_CATH_3.30.200.20_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6mm6</span> contains 2 copies of CATH domain <span class='highlight'>3.30.200.20 (Phosphorylase Kinase; domain 1)</span> in <span class='highlight'>cAMP-dependent protein kinase catalytic subunit alpha</span>. Showing 1 copy in chain <span class='highlight'>A [auth C]</span>.")
![The deposited structure of PDB entry 6mm6 contains 2 copies of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in cAMP-dependent protein kinase catalytic subunit alpha. Showing 1 copy in chain A [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6mm6_1_C_CATH_1.10.510.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6mm6</span> contains 2 copies of CATH domain <span class='highlight'>1.10.510.10 (Transferase(Phosphotransferase); domain 1)</span> in <span class='highlight'>cAMP-dependent protein kinase catalytic subunit alpha</span>. Showing 1 copy in chain <span class='highlight'>A [auth C]</span>.")