› 6mj2

Electron Microscopy
6.36Å resolution

Human TRPM2 ion channel in a calcium- and ADPR-bound state

Released:
DOI: 10.2210/pdb6mj2/pdb
PDB entry 6mj2 coloured by chain, front view.
PDB entry 6mj2 coloured by chain, side view.
PDB entry 6mj2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures and gating mechanism of human TRPM2.
Wang L, Fu TM, Zhou Y, Xia S, Greka A, Wu H
Science 362 (2018)
PMID: 30467180
Related structures: EMD-9134

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1503 amino acids
Theoretical weight: 171.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O94759 (Residues: 1-1503; Coverage: 100%)
Gene names: EREG1, KNP3, LTRPC2, TRPC7, TRPM2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.36Å
Relevant EMDB volumes: EMD-9134
Expression system: Homo sapiens

Quick links

Citations

30 review citations

TRPM2 in Cancer.
Miller BA. (2019)
29 more

10 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
9 more