› 6mie

Solution NMR

Solution NMR structure of the KCNQ1 voltage-sensing domain

Released:
DOI: 10.2210/pdb6mie/pdb
PDB entry 6mie coloured by chain, ensemble of 10 models, front view.
PDB entry 6mie coloured by chain, ensemble of 10 models, side view.
PDB entry 6mie coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state.
Taylor KC, Kang PW, Hou P, Yang ND, Kuenze G, Smith JA, Shi J, Huang H, White KM, Peng D, George AL, Meiler J, McFeeters RL, Cui J, Sanders CR
Elife 9 (2020)
PMID: 32096762

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156413 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily KQT member 1 Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 18.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51787 (Residues: 100-249; Coverage: 22%)
Gene names: KCNA8, KCNA9, KCNQ1, KVLQT1
Sequence domains: Ion transport protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 70%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Insights into Cardiac IKs (KCNQ1/KCNE1) Channels Regulation.
Wu et al. (2020)
3 more

4 mentions without citation

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state.
Taylor et al. (2020)
3 more