› 6mh4

X-ray diffraction
2.15Å resolution

Crystal Structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Staphylococcus schleiferi, Apoenzyme

Released:
DOI: 10.2210/pdb6mh4/pdb
PDB entry 6mh4 coloured by chain, front view.
PDB entry 6mh4 coloured by chain, side view.
PDB entry 6mh4 coloured by chain, top view.
Source organism: Staphylococcus schleiferi
Primary publication:
Potent, specific MEPicides for treatment of zoonotic staphylococci.
Edwards RL, Heueck I, Lee SG, Shah IT, Miller JJ, Jezewski AJ, Mikati MO, Wang X, Brothers RC, Heidel KM, Osbourn DM, Burnham CD, Alvarez S, Fritz SA, Dowd CS, Jez JM, Odom John AR
PLoS Pathog 16 e1007806 (2020)
PMID: 32497104

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-237339 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-deoxy-D-xylulose 5-phosphate reductoisomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 376 amino acids
Theoretical weight: 42.25 KDa
Source organism: Staphylococcus schleiferi
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3112
Unit cell:
a: 71.368Å b: 71.368Å c: 318.815Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.197 0.23
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities.
Knak et al. (2022)
4 other articles

1 mention without citation

Potent, specific MEPicides for treatment of zoonotic staphylococci.
Edwards et al. (2020)