6mft

X-ray diffraction
2.32Å resolution

Crystal structure of glycosylated 426c HIV-1 gp120 core G459C in complex with glVRC01 A60C heavy chain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Heavy Chain glVRC01 Chains: A, H
Molecule details ›
Chains: A, H
Length: 233 amino acids
Theoretical weight: 25.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain glVRC01 Chains: B, L
Molecule details ›
Chains: B, L
Length: 210 amino acids
Theoretical weight: 23.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Envelope glycoprotein gp160 Chains: C, G
Molecule details ›
Chains: C, G
Length: 347 amino acids
Theoretical weight: 38.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: M4Q8P8 (Residues: 39-479; Coverage: 52%)
Gene name: env

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 197.082Å b: 109.003Å c: 103.225Å
α: 90° β: 114.47° γ: 90°
R-values:
R R work R free
0.246 0.244 0.295
Expression system: Homo sapiens