› 6m9m

X-ray diffraction
1.4Å resolution

Streptococcus mutans AlkD2 bound to inosine-5'-monophosphate

Released:
DOI: 10.2210/pdb6m9m/pdb
PDB entry 6m9m coloured by chain, front view.
PDB entry 6m9m coloured by chain, side view.
PDB entry 6m9m coloured by chain, top view.
Source organism: Streptococcus mutans
Primary publication:
Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases.
Shi R, Shen XX, Rokas A, Eichman BF
Bioessays 40 e1800133 (2018)
PMID: 30264543

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102445 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphomethylpyrimidine kinase Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 24.58 KDa
Source organism: Streptococcus mutans
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0M3KL00 (Residues: 4-210; Coverage: 99%)
Gene name: ALKD2
Sequence domains: DNA alkylation repair enzyme
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand IMP 1 x IMP
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 60.152Å b: 63.041Å c: 65.546Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.138 0.136 0.173
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway.
Mullins et al. (2019)
3 more