Function and Biology Details
Reaction catalysed:
Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Pyridoxal phosphate-dependent transferase, major domain
- Aminotransferase, class I/classII
- Pyridoxal phosphate-dependent transferase, small domain
- Pyridoxal phosphate-dependent transferase
- ORMDL family
- Aminotransferase, class-II, pyridoxal-phosphate binding site
- Small subunit of serine palmitoyltransferase-like
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-127403 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Serine palmitoyltransferase 1
Molecule details ›
Chains: B, S
Length: 473 amino acids
Theoretical weight: 52.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Aminotransferase class I and II
Length: 473 amino acids
Theoretical weight: 52.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
O15269 (Residues: 1-473; Coverage: 100%)
Sequence domains: Aminotransferase class I and II
Serine palmitoyltransferase 2
Molecule details ›
Chain: T
Length: 562 amino acids
Theoretical weight: 63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Aminotransferase class I and II
Length: 562 amino acids
Theoretical weight: 63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: O15270 (Residues: 1-562; Coverage: 100%)
Sequence domains: Aminotransferase class I and II
ORM1-like protein 3
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: ORMDL family
Length: 153 amino acids
Theoretical weight: 17.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q8N138 (Residues: 1-153; Coverage: 100%)
Sequence domains: ORMDL family
Serine palmitoyltransferase small subunit A
Molecule details ›
Chain: E
Length: 92 amino acids
Theoretical weight: 10.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Small subunit of serine palmitoyltransferase-like
Length: 92 amino acids
Theoretical weight: 10.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q969W0 (Residues: 1-71; Coverage: 100%)
Sequence domains: Small subunit of serine palmitoyltransferase-like
