6m17

Electron Microscopy
2.9Å resolution

The 2019-nCoV RBD/ACE2-B0AT1 complex

Released:

Function and Biology Details

Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Sodium-dependent neutral amino acid transporter B(0)AT1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 654 amino acids
Theoretical weight: 73.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q695T7 (Residues: 2-634; Coverage: 100%)
Gene names: B0AT1, SLC6A19
Sequence domains: Sodium:neurotransmitter symporter family
Angiotensin-converting enzyme 2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 814 amino acids
Theoretical weight: 93.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 2-17, 18-805; Coverage: 100%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains:
Spike protein S1 Chains: E, F
Molecule details ›
Chains: E, F
Length: 223 amino acids
Theoretical weight: 25.12 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-30039
Expression system: Homo sapiens