6m11

X-ray diffraction
2.46Å resolution

Crystal structure of Rnase L in complex with Sunitinib

Released:
Source organism: Sus scrofa
Entry authors: Tang J, Huang H

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease L Chains: a, b
Molecule details ›
Chains: a, b
Length: 717 amino acids
Theoretical weight: 81.33 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: A5H025 (Residues: 21-732; Coverage: 96%)
Gene name: RNASEL
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 59.24Å b: 111Å c: 262.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.22 0.285
Expression system: Escherichia coli