Structure analysis

t8E4 antibody Fab complexed with the active form of HGF

X-ray diffraction
2.8Å resolution
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 28500 Å2
Buried surface area: 6400 Å2
Dissociation area: 1,000 Å2
Dissociation energy (ΔGdiss): -2 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -36 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 108 amino acids
Theoretical weight: 12.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P14210 (Residues: 388-494; Coverage: 15%)
Gene names: HGF, HPTA
Pfam: Kringle domain

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Chain: B
Length: 242 amino acids
Theoretical weight: 27.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P14210 (Residues: 495-728; Coverage: 34%)
Gene names: HGF, HPTA
Pfam: Trypsin

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Chain: H
Length: 223 amino acids
Theoretical weight: 24.08 KDa
Source organism: Mus musculus
Expression system: hybrid

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Chain: L
Length: 214 amino acids
Theoretical weight: 23.85 KDa
Source organism: Mus musculus
Expression system: hybrid

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