› 6loc

X-ray diffraction
2.2Å resolution

Crystal structure of RORgammat with ligand C46D bound

Released:
DOI: 10.2210/pdb6loc/pdb
PDB entry 6loc coloured by chain, front view.
PDB entry 6loc coloured by chain, side view.
PDB entry 6loc coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Feng Y, Shijie C

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156324 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor ROR-gamma Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 32.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51449 (Residues: 260-507; Coverage: 48%)
Gene names: NR1F3, RORC, RORG, RZRG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand EKL 1 x EKL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P41212
Unit cell:
a: 61.15Å b: 61.15Å c: 156.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.195 0.251
Expression system: Escherichia coli

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