› 6ln6

Electron Microscopy
2.9Å resolution

CryoEM structure of SERCA2b T1032stop in E1-2Ca2+-AMPPCP (class2)

Released:
DOI: 10.2210/pdb6ln6/pdb
PDB entry 6ln6 coloured by chain, front view.
PDB entry 6ln6 coloured by chain, side view.
PDB entry 6ln6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail.
Zhang Y, Inoue M, Tsutsumi A, Watanabe S, Nishizawa T, Nagata K, Kikkawa M, Inaba K
Sci Adv 6 eabb0147 (2020)
PMID: 32851169
Related structures: EMD-0925

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Chain: A
Molecule details ›
Chain: A
Length: 1059 amino acids
Theoretical weight: 116.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16615 (Residues: 1-1031; Coverage: 99%)
Gene names: ATP2A2, ATP2B
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ACP 1 x ACP
Ligand MG 1 x MG
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-0925
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Pathways for Sensing and Responding to Hydrogen Peroxide at the Endoplasmic Reticulum.
Roscoe et al. (2020)
5 more