Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Immunoglobulin C1-set
- MHC class I alpha chain, alpha1 alpha2 domains
- Beta-2-Microglobulin
- Immunoglobulin/major histocompatibility complex, conserved site
- Immunoglobulin-like domain superfamily
- Immunoglobulin-like domain
- Immunoglobulin-like fold
- MHC classes I/II-like antigen recognition protein
2 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134978 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H-2 class I histocompatibility antigen, L-D alpha chain
Molecule details ›
Chains: A, D, G, J
Length: 278 amino acids
Theoretical weight: 32.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 278 amino acids
Theoretical weight: 32.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P01897 (Residues: 24-301; Coverage: 82%)
Sequence domains:
Beta-2-microglobulin
Molecule details ›
Chains: B, E, H, K
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Immunoglobulin C1-set domain
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Sequence domains: Immunoglobulin C1-set domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.2.2
Spacegroup:
P1
Expression systems:
- Escherichia coli
- synthetic construct
