› 6l75

X-ray diffraction
1.58Å resolution

Crystal structure of d(GTGGGCCGAC)2 DNA duplex

Released:
DOI: 10.2210/pdb6l75/pdb
PDB entry 6l75 coloured by chain, front view.
PDB entry 6l75 coloured by chain, side view.
PDB entry 6l75 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction.
Jhan CR, Satange R, Wang SC, Zeng JY, Horng YC, Jin P, Neidle S, Hou MH
Nucleic Acids Res 49 9526-9538 (2021)
PMID: 33836081

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120192 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(P*GP*TP*GP*GP*GP*CP*CP*GP*AP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 10 nucleotides
Theoretical weight: 3.09 KDa
Source organism: synthetic construct
Expression system: Not provided
DNA (5'-D(P*GP*TP*GP*GP*GP*CP*CP*GP*AP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 10 nucleotides
Theoretical weight: 3.01 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL15A1
Spacegroup: P3121
Unit cell:
a: 38.457Å b: 38.457Å c: 79.935Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.199 0.228
Expression system: Not provided

Quick links

Citations

2 mentions without citation

Knowledge-based prediction of DNA hydration using hydrated dinucleotides as building blocks.
Biedermannová et al. (2022)
1 more