› 6kxa

X-ray diffraction
1.23Å resolution

Galectin-3 CRD binds to GalA dimer

Released:
DOI: 10.2210/pdb6kxa/pdb
PDB entry 6kxa coloured by chain, front view.
PDB entry 6kxa coloured by chain, side view.
PDB entry 6kxa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Topsy-turvy binding of negatively charged homogalacturonan oligosaccharides to galectin-3.
Zheng Y, Su J, Miller MC, Geng J, Xu X, Zhang T, Mayzel M, Zhou Y, Mayo KH, Tai G
Glycobiology 31 341-350 (2021)
PMID: 32909036

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-3 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17931 (Residues: 113-250; Coverage: 55%)
Gene names: LGALS3, MAC2
Sequence domains: Galactoside-binding lectin

Ligands and Environments

Carbohydrate polymer : NEW Components: GTR, ADA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 35.876Å b: 57.276Å c: 61.867Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.166 0.184
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The Complex Biological Effects of Pectin: Galectin-3 Targeting as Potential Human Health Improvement?
Pedrosa et al. (2022)
2 more