6kva

X-ray diffraction
2.2Å resolution

Structure of anti-hCXCR2 abN48-2 in complex with its CXCR2 epitope

Released:
Source organism: Homo sapiens
Entry authors: Xiang JC, Yan L, Yang B, Wilson IA

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
heavy chain Chains: H, h
Molecule details ›
Chains: H, h
Length: 227 amino acids
Theoretical weight: 24.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
light chain Chains: L, l
Molecule details ›
Chains: L, l
Length: 222 amino acids
Theoretical weight: 23.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
C-X-C chemokine receptor type 2 Chains: B, b
Molecule details ›
Chains: B, b
Length: 11 amino acids
Theoretical weight: 1.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P25025 (Residues: 9-19; Coverage: 3%)
Gene names: CXCR2, IL8RB

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 66.685Å b: 96.337Å c: 70.783Å
α: 90° β: 109.86° γ: 90°
R-values:
R R work R free
0.196 0.194 0.234
Expression systems:
  • Homo sapiens
  • Not provided