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Human PPARgamma ligand-binding domain R288A mutant in complex with imatinib

Source organism: Homo sapiens
Biochemical function: nuclear receptor activity
Biological process: regulation of DNA-templated transcription
Cellular component: nucleus

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Peroxisome proliferator-activated receptor gamma
The deposited structure of PDB entry 6ktn contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Peroxisome proliferator-activated receptor gamma. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003074
Domain description: Peroxisome proliferator-activated receptor
Occurring in:
  1. Peroxisome proliferator-activated receptor gamma
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Peroxisome proliferator-activated receptor gamma
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Peroxisome proliferator-activated receptor gamma
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Peroxisome proliferator-activated receptor gamma
IPR014935
Domain description: Nuclear receptor coactivator, receptor-binding domain
Occurring in:
  1. Nuclear receptor coactivator 1
IPR013809
Domain description: ENTH domain
Occurring in:
  1. Nuclear receptor coactivator 1

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