› 6kee

X-ray diffraction
2.12Å resolution

Crystal structure of BRD4 Bromodomain1 with an inhibitor

Released:
DOI: 10.2210/pdb6kee/pdb
PDB 6kee coloured by chain and viewed from the front.
PDB 6kee coloured by chain and viewed from the side.
PDB 6kee coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Xiao S, Li Z, Chen S, Zhou B, Luo C

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand D7U 1 x D7U
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 32.737Å b: 47.703Å c: 79.537Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.203 0.274
Expression system: Escherichia coli

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