› 6k9g

X-ray diffraction
2.8Å resolution

Human LXR-beta in complex with an agonist

Released:
DOI: 10.2210/pdb6k9g/pdb
PDB entry 6k9g coloured by chain, front view.
PDB entry 6k9g coloured by chain, side view.
PDB entry 6k9g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of new LXRβ agonists as glioblastoma inhibitors.
Chen H, Chen Z, Zhang Z, Li Y, Zhang S, Jiang F, Wei J, Ding P, Zhou H, Gu Q, Xu J
Eur J Med Chem 194 112240 (2020)
PMID: 32248003

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 274 amino acids
Theoretical weight: 31.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55055 (Residues: 214-460; Coverage: 54%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand D3R 4 x D3R
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 67.433Å b: 103.739Å c: 152.233Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.262 0.261 0.281
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Cholesterol metabolism and its implication in glioblastoma therapy.
Guo et al. (2022)
1 more