› 6k8j

Electron Microscopy
3.3Å resolution

Structure of NLRC4 CARD filament

Released:
DOI: 10.2210/pdb6k8j/pdb
PDB entry 6k8j coloured by chain, front view.
PDB entry 6k8j coloured by chain, side view.
PDB entry 6k8j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Gong Q, Robinson K, Xu C, Huynh PT, Chong KHC, Tan EYJ, Zhang J, Boo ZZ, Teo DET, Lay K, Zhang Y, Lim JSY, Goh WI, Wright G, Zhong FL, Reversade B, Wu B
Nat Commun 12 188 (2021)
PMID: 33420028
Related structures: EMD-9946

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192490 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NLR family CARD domain-containing protein 4 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 101 amino acids
Theoretical weight: 11.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q9NPP4 (Residues: 1-85; Coverage: 8%)
Gene names: CARD12, CLAN, CLAN1, IPAF, NLRC4, UNQ6189/PRO20215
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-9946
Expression system: Escherichia coli K-12

Quick links

Citations

17 review citations

Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.
Fu et al. (2023)
16 more

1 mention without citation

Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Matico et al. (2024)