6k1q

X-ray diffraction
2.7Å resolution

Human endothelin receptor type-B in complex with inverse agonist IRL2500

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endolysin; Endothelin receptor type B Chain: A
Molecule details ›
Chain: A
Length: 464 amino acids
Theoretical weight: 52.13 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24530 (Residues: 66-303, 311-407; Coverage: 81%)
  • Canonical: P00720 (Residues: 61-161; Coverage: 62%)
Gene names: E, EDNRB, ETRB
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: I422
Unit cell:
a: 109.91Å b: 109.91Å c: 291.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.265
Expression system: Spodoptera frugiperda