PDBe 6k1e

X-ray diffraction
2.9Å resolution

Crystal structure of EXD2 exonuclease domain soaked in Mg and GMP

Released:
Source organism: Homo sapiens
Entry authors: Park J, Lee C

Function and Biology Details

Reaction catalysed:
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Exonuclease 3'-5' domain-containing protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 220 amino acids
Theoretical weight: 24.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NVH0 (Residues: 76-295; Coverage: 35%)
Gene names: C14orf114, EXD2, EXDL2
Sequence domains: 3'-5' exonuclease

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 11C
Spacegroup: P212121
Unit cell:
a: 46.496Å b: 73.288Å c: 134.086Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.268
Expression system: Escherichia coli