Function and Biology Details
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140110 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Small ubiquitin-related modifier 2
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 10.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin-2 like Rad60 SUMO-like
Length: 95 amino acids
Theoretical weight: 10.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P61956 (Residues: 1-95; Coverage: 100%)
Sequence domains: Ubiquitin-2 like Rad60 SUMO-like
E3 ubiquitin-protein ligase ICP0
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.16 KDa
Source organism: Human alphaherpesvirus 1
Expression system: Not provided
UniProt:
Length: 20 amino acids
Theoretical weight: 2.16 KDa
Source organism: Human alphaherpesvirus 1
Expression system: Not provided
UniProt:
- Canonical: P08393 (Residues: 355-374; Coverage: 3%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Chemical shift assignment:
79%
Refinement method:
simulated annealing
Expression systems:
- Escherichia coli
- Not provided
