PDBe 6jxr

Electron Microscopy
3.7Å resolution

Structure of a protein

Released:
Source organism: Homo sapiens
Related structures: EMD-9895

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
T-cell surface glycoprotein CD3 zeta chain Chains: a, b
Molecule details ›
Chains: a, b
Length: 164 amino acids
Theoretical weight: 18.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20963 (Residues: 1-164; Coverage: 100%)
Gene names: CD247, CD3Z, T3Z, TCRZ
Sequence domains:
T-cell surface glycoprotein CD3 delta chain Chain: d
Molecule details ›
Chain: d
Length: 171 amino acids
Theoretical weight: 18.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04234 (Residues: 1-171; Coverage: 100%)
Gene names: CD3D, T3D
Sequence domains:
T-cell surface glycoprotein CD3 epsilon chain Chains: e, f
Molecule details ›
Chains: e, f
Length: 207 amino acids
Theoretical weight: 23.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P07766 (Residues: 1-207; Coverage: 100%)
Gene names: CD3E, T3E
Sequence domains:
T-cell surface glycoprotein CD3 gamma chain Chain: g
Molecule details ›
Chain: g
Length: 182 amino acids
Theoretical weight: 20.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09693 (Residues: 1-182; Coverage: 100%)
Gene names: CD3G, T3G
Sequence domains:
Possible J 11 gene segment; T cell receptor alpha constant; T cell receptor alpha variable 12-3 Chain: m
Molecule details ›
Chain: m
Length: 252 amino acids
Theoretical weight: 28.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01848 (Residues: 1-140; Coverage: 100%)
  • Canonical: A0N4Z6 (Residues: 4-20; Coverage: 85%)
  • Canonical: A0A0B4J271 (Residues: 22-114; Coverage: 100%)
Gene names: TCRA, TRAC, TRAV12-3, Tcr-alpha
Sequence domains:
Ig-like domain-containing protein; M1-specific T cell receptor beta chain; T cell receptor beta variable 6-5 Chain: n
Molecule details ›
Chain: n
Length: 291 amino acids
Theoretical weight: 32.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0G2JMB4 (Residues: 10-179; Coverage: 95%)
  • Canonical: A0A0K0K1A5 (Residues: 23-112; Coverage: 97%)
  • Canonical: P0DSE2 (Residues: 22-22, 119-140; Coverage: 8%)
Gene names: TRB, TRBC2, TRBV6-5
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-9895
Expression system: Homo sapiens