› 6jpj

X-ray diffraction
2.64Å resolution

Crystal structure of FGF401 in complex of FGFR4

Released:
DOI: 10.2210/pdb6jpj/pdb
PDB entry 6jpj coloured by chain, front view.
PDB entry 6jpj coloured by chain, side view.
PDB entry 6jpj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.
Zhou Z, Chen X, Fu Y, Zhang Y, Dai S, Li J, Chen L, Xu G, Chen Z, Chen Y
Chem Commun (Camb) 55 5890-5893 (2019)
PMID: 31041948

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149636 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 34.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22455 (Residues: 445-753; Coverage: 40%)
Gene names: FGFR4, JTK2, TKF
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FGF 1 x FGF
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: Cu FINE FOCUS
Spacegroup: P21
Unit cell:
a: 42.275Å b: 60.931Å c: 61.154Å
α: 90° β: 98.56° γ: 90°
R-values:
R R work R free
0.198 0.195 0.243
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Dissecting the Role of the FGF19-FGFR4 Signaling Pathway in Cancer Development and Progression.
Liu et al. (2020)
2 more

4 mentions without citation

Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors.
Dai et al. (2019)
3 more