› 6jmd

X-ray diffraction
1.78Å resolution

Function and Biology Details

Reaction catalysed: 
(S)-dihydroorotate + a quinone = orotate + a quinol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydroorotate dehydrogenase (quinone), mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 39.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02127 (Residues: 30-395; Coverage: 93%)
Gene name: DHODH
Sequence domains: Dihydroorotate dehydrogenase

Ligands and Environments


Cofactor: Ligand FMN 1 x FMN
5 bound ligands:
Ligand ORO 1 x ORO
Ligand SO4 2 x SO4
Ligand ACT 2 x ACT
Ligand LDA 1 x LDA
Ligand BVO 1 x BVO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P3221
Unit cell:
a: 90.627Å b: 90.627Å c: 123.169Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.155 0.155 0.177
Expression system: Escherichia coli

Quick links

Citations

1 review citation

DHODH and cancer: promising prospects to be explored.
Zhou et al. (2021)
4 other articles

1 mention without citation

A comprehensive drug repurposing study for COVID19 treatment: novel putative dihydroorotate dehydrogenase inhibitors show association to serotonin-dopamine receptors.
Berber et al. (2021)