X-ray diffraction
1.57Å resolution

Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 2-8-s2


Function and Biology Details

Reaction catalysed:
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Chitotriosidase-1 Chain: A
Molecule details ›
Chain: A
Length: 381 amino acids
Theoretical weight: 42.67 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
  • Canonical: Q13231 (Residues: 22-396; Coverage: 84%)
  • Best match: Q13231-2 (Residues: 22-386)
Gene name: CHIT1
Sequence domains: Glycosyl hydrolases family 18

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NFPSS BEAMLINE BL19U1
Spacegroup: P43
Unit cell:
a: 66.726Å b: 66.726Å c: 88.363Å
α: 90° β: 90° γ: 90°
R R work R free
0.167 0.166 0.188
Expression system: Komagataella phaffii GS115