6jj6

X-ray diffraction
1.4Å resolution

BRD4 in complex with 500

Released:
Source organism: Homo sapiens
Entry authors: Xu J, Chen Y, Jiang F, Zhu J

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60885 (Residues: 44-167; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 31.8Å b: 47.12Å c: 79.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.201
Expression system: Escherichia coli BL21(DE3)