› 6jj6

X-ray diffraction
1.4Å resolution

BRD4 in complex with 500

Released:
DOI: 10.2210/pdb6jj6/pdb
PDB 6jj6 coloured by chain and viewed from the front.
PDB 6jj6 coloured by chain and viewed from the side.
PDB 6jj6 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Xu J, Chen Y, Jiang F, Zhu J

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60885 (Residues: 44-167; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand C89 1 x C89
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 31.8Å b: 47.12Å c: 79.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.201
Expression system: Escherichia coli BL21(DE3)

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