Function and Biology

Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (Y1755 down)

Source organism: Homo sapiens
Biochemical function: sodium channel regulator activity
Biological process: sodium ion transport
Cellular component: membrane

Sequence families

Pfam Protein families (Pfam)
PF00520
Domain description: Ion transport protein
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
The deposited structure of PDB entry 6j8j contains 4 copies of Pfam domain PF00520 (Ion transport protein) in Sodium channel protein type 9 subunit alpha. Showing 4 copies in chain B [auth A].

PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Sodium channel subunit beta-1
  2. Sodium channel subunit beta-2
The deposited structure of PDB entry 6j8j contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Sodium channel subunit beta-2. Showing 1 copy in chain A [auth C].
The deposited structure of PDB entry 6j8j contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Sodium channel subunit beta-1. Showing 1 copy in chain C [auth B].

PF06512
Domain description: Sodium ion transport-associated
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
The deposited structure of PDB entry 6j8j contains 1 copy of Pfam domain PF06512 (Sodium ion transport-associated) in Sodium channel protein type 9 subunit alpha. Showing 1 copy in chain B [auth A].

PF11933
Domain description: Cytoplasmic domain of voltage-gated Na+ ion channel
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
The deposited structure of PDB entry 6j8j contains 1 copy of Pfam domain PF11933 (Cytoplasmic domain of voltage-gated Na+ ion channel) in Sodium channel protein type 9 subunit alpha. Showing 1 copy in chain B [auth A] (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR000920
Domain description: Myelin P0 protein-related
Occurring in:
  1. Sodium channel subunit beta-2
IPR005821
Domain description: Ion transport domain
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
IPR027359
Domain description: Voltage-dependent channel domain superfamily
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Sodium channel subunit beta-1
  2. Sodium channel subunit beta-2
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Sodium channel subunit beta-1
  2. Sodium channel subunit beta-2
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Sodium channel subunit beta-1
  2. Sodium channel subunit beta-2
IPR001696
Domain description: Voltage gated sodium channel, alpha subunit
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Sodium channel subunit beta-2
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Sodium channel subunit beta-2
IPR027098
Domain description: Sodium channel subunit beta-1/beta-3
Occurring in:
  1. Sodium channel subunit beta-1
IPR000048
Domain description: IQ motif, EF-hand binding site
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
IPR044564
Domain description: Voltage-gated sodium channel alpha subunit, inactivation gate
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
IPR010526
Domain description: Sodium ion transport-associated domain
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
IPR024583
Domain description: Voltage-gated Na+ ion channel, cytoplasmic domain
Occurring in:
  1. Sodium channel protein type 9 subunit alpha
IPR043203
Domain description: Voltage-gated cation channel calcium and sodium
Occurring in:
  1. Sodium channel protein type 9 subunit alpha

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Sodium channel subunit beta-2
The deposited structure of PDB entry 6j8j contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Sodium channel subunit beta-2. Showing 1 copy in chain A [auth C].