› 6j7w

X-ray diffraction
2.6Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211893 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
UniAb Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 12.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Tumor necrosis factor receptor superfamily member 17 Chains: C, D
Molecule details ›
Chains: C, D
Length: 39 amino acids
Theoretical weight: 4.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02223 (Residues: 6-44; Coverage: 21%)
Gene names: BCM, BCMA, TNFRSF17
Sequence domains: BCMA, TALL-1 binding

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2221
Unit cell:
a: 65.392Å b: 73.806Å c: 133.491Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.208 0.271
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Immunogenicity of CAR T cells in cancer therapy.
Wagner et al. (2021)
7 more

1 mention without citation

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity.
Sun et al. (2023)